KMID : 0358420160590060470
|
|
Korean Journal of Obstetrics and Gynecology 2016 Volume.59 No. 6 p.470 ~ p.478
|
|
Glycogen synthase kinase 3¥â and cyclin D1 expression in cervical carcinogenesis
|
|
Park Hyun-Soo
Lee Myung-Hwa Kim Dae-Woon Hong Seo-Yoo Lee Ho-Jung
|
|
Abstract
|
|
|
Objective: Glycogen synthase kinase 3¥â (GSK3¥â) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1 to S phase transition in various cells, is one of target proteins that GSK3¥â regulate. Our objective was to assess the expression of GSK3¥â and cyclin D1 in cervical neoplasm of different histologic grades and to identify their correlation in cervical carcinogenesis.
Methods: Immunohistochemical analysis of GSK3¥â and cyclin D1 was performed in a total of 137 patients with 12 normal, 62 cervical intraepithelial neoplasia (CIN) (31 CIN1 and 31 CIN3) and 63 invasive cancers including 56 squamous cell carcinomas and 7 adenocarcinomas.
Results: The expression of GSK3¥â increased in parallel with the lesion grade, while that of cyclin D1 decreased with severity of the lesion (P<0.001). There was a significant inverse correlation between GSK3¥â and cyclin D1 expression in overall cervical neoplasia (¥Õ=-0.413, P<0.001). GSK3¥â expression was higher in squamous cell carcinoma than in adenocarcinoma (P=0.049).
Conclusion: These results suggest that the expressional increase in GSK3¥â plays a role in cervical carcinogenesis and has inverse correlation with cyclin D1 expression in this process. In addition, GSK3¥â expression appears to be associated with the histologic type of cervical cancer, especially squamous cell carcinoma.
|
|
KEYWORD
|
|
Cervical intraepithelial neoplasia, Cyclin D1, Glycogen synthase kinase 3 beta, Immunohistochemistry, Squamous cell carcinoma
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|